A 21st Century Breakthrough in Ginseng Science: Enzyme Formulation

:dropcap_open:G:dropcap_close:inseng is one of the most well-known of all herbal remedies, and the history of ginseng in natural medicine goes back thousands of years, first mentioned in written medical journals in China over 2,000 years ago. Ginseng is considered the most powerful adaptogenic herb. In fact, ginseng has become the standard by which all other adaptogens are measured. This is why Suma is called Brazilian Ginseng, Maca is called Peruvian Ginseng, Ashwaganda is called Indian Ginseng, and Eleuthero Root is called Siberian Ginseng. None of these common adoptogens are ginseng, yet they are called ginseng. There are 4 types of actual ginsengs which have the plant classification Panax: Korean Ginseng (Panax CA Meyer), Chinese Ginseng (Tianchi Ginseng), American Ginseng (Panax quinquefolius) and Japanese Ginseng (Ginex Japonicus).

ginsengroot3So what is an adaptogen? According to Webster’s Dictionary, “an adaptogen is a nontoxic substance and especially a plant extract that is held to increase the body’s ability to resist the damaging effects of stress and promote or restore normal physiological functioning”. In medical terms, a highly efficacious adaptogen helps to bring the body into homeostatic balance.

How does Ginseng work?
Why has it been the leading herbal remedy for 2,000 years for such a broad range of conditions?

A simple answer is that when the body reaches a homeostatic state its ability to self-heal is optimized. This is no secret for a chiropractic physician. Through making adjustments and removing subluxations we allow the energy in the body to flow naturally and in balance.The result is the body begins to heal itself; this is how it is designed!

So how does Panax Ginseng bring the body into balance?
ginsengchart1In 1963 the unique active ingredient found only in Panax ginseng was discovered, plant triterpene saponins called ginsenosides. The number of different types of ginsenosides determines the range of the adaptogenic capacity of the ginseng. Different ginsenosides have shown in clinical research to have different effects, sometimes opposing effects. For example, some increase blood pressure while others reduce blood pressure, some increase blood glucose while others reduce blood glucose. The ginsenosides in combination with the 32 minerals, 14 amino acids, organic germanium and 7 vitamins and polysaccharides make a remarkable synergy that bring the body into balance.
A fully balanced ginseng has tremendous potential. It must be harvested after the optimal length of time, 4 or 5 years, processed as a whole root without peeling, allowed to dry without high heat steam and finally extracted using a low heat vacuum extraction. The result is a remarkably balanced extract with the potential to improve human health.

Ginseng and Chiropractic Care
High Quality Ginseng is an ideal complement to chiropractic treatment. It works synergistically to bring the body into balance and optimize the body’s self-healing potential.

Fermented Ginseng: A 21st century breakthrough in Ginseng Science
“The therapeutic potential of ginseng has been studied extensively, and ginsenosides, the active components of ginseng, are shown to be involved in modulating multiple physiological activities. These molecules exert their functions via interactions with steroidal receptors. The multiple biological actions make ginsenosides important resources for developing new modalities. Yet, low bioavailability of ginsenoside is one of the major hurdles that needs to be overcome to advance its use in clinical settings.” *Pharmacology of ginsenosides: a literature review Kar W Leung* and Alice ST Wong, CMJ Journal, June 2010.

The Challenge: Absorption
There are two main types of ginsenosides: the Protopanaxadiol “Diol Type” and Protopanaxotriol “Triol Type”. The Diol type ginsenosides have been shown in research to have the greatest medicinal efficacy. However, the Diol type ginsenosides have a larger molecular size. A scientific discovery in the late 90s showed that many of the ginsenosides were not being absorbed until they reached the large intestine in the ascending colon. A related problem surfaced in other clinical studies showing that many people were not experiencing full absorption. In one study less than 40% of the subjects were able to have full absorption of all ginsenosides.

The Solution: Create Ginsenoside Metabolites via Fermentation

As we enter 2012, more and more research on the benefits of fermentation as it facilitates digestion and absorption has been made available. This has also been part of the development of ginseng science.

In the 90s, research began in earnest to find a way to improve absorption. The first research was done in the late 90s and utilized human bacteria to create the metabolites of ginsenosides.

In the main area of research the metabolite form of the Diol type ginsenosides became known as “IH 901” or “Compound K”. Ginseng research then expanded.

In 2008 a superior process was developed using enzyme fermentation. The result was overwhelming. In a 2×2 crossover study with 24 healthy male subjects, the enzyme fermented ginseng extract vs. standard ginseng extract showed 15 times increased absorption, 4 times faster absorption and 4 times increased consistency of absorption. *Pharmacokinetic comparison of ginsenoside metabolite IH-901 from fermented and non-fermented ginseng in healthy Korean volunteers. ( Journal of Ethnopharmacology 139 (2012) 664– 667.)

Now, high absorption, fully-balanced ginseng is available in the market.

Good diet, high quality water, and exercise are all essential components of optimum wellness. We are facing an overwhelming amount of stress and toxicity in our environment. Our bodies need extra help, and the leading natural medicine for several thousand years has been made available using 21st century science.

Now, enzyme fermented ginseng extract can be fully absorbed to provide its balancing effect for bringing everyone’s body into homeostatic balance and optimizing wellness.

Research Opportunities
Today, Doctors can participate in a longitudinal case study with high absorption Enzyme Fermented Ginseng Extract conducted by the Clinic Research Institute.

Each participating physician receives over $450 worth of an enzyme fermented high-absorption ginseng (patent pending) for testing with 3 patients.

To learn more contact CRI at 877-532-8378 or go to www.ClinicResearchInstitute.org

Ronald K. Gilbert, D.C., CCSP, NMD B.S. 1984, Va Commonwealth Univ. 1985, Diplomate, National Board of Chiropractic Examiners D.C 1986, Northwestern College CCSP 1988, Parker College, Sports Medicine 1992 , American Board of Chiropractic Orthopedics NMD 2002, St Luke School of Naturopathic Medicine,, ND 2002, Commission on Certification of Naturopathic Physicians 2002 ,100 hr. Post-Grad Internal Medicine, National University of Health Sciences.

David C. Konn, Double Major Psychology and Kinesiology, Macalester College, St Paul MN, Patent Holder CEO, Neuro Energies Inc. Regional President, Empowered Doctor Managing Director, Ilhwa North America President/CEO, Ilhwa NA Inc.

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