KEY POINTS FROM DR. DAN MURPHY
1) In chronic low back pain, there is an integration between connective tissue fibrosis and the nervous system perception of pain.
2) Adverse connective tissue fibrosis can be remodeled by applying mechanical forces to soft tissues, including chiropractic spinal adjusting. [Note, chiropractic was included as the applying of a mechanical force to reverse adverse connective tissue fibrosis and its influence on the nervous system.]
3) The “association between symptoms and imaging results (X-ray, CT, MRI) has been consistently weak, and up to 85 percent of patients with low back pain cannot be given a precise pathoanatomical diagnosis using these methods.”
4) “Ongoing pain is associated with widespread neuroplastic changes at multiple levels within the nervous system and including primary afferent neurons, spinal cord, brainstem, thalamus, limbic system and cortex.”
5) Neuroimaging has shown that there are distinct “brain networks” involved in acute vs. chronic pain. Chronic pain is specifically related to regions for cognition and emotions.
6) Chronic back pain results in neuronal or glial loss in the pre-frontal and thalamic gray matter. [Brain atrophy]
7) “Increased connective tissue stiffness due to fibrosis is an important link in the pathogenic mechanism leading to chronicity of pain.” [Very Important: The Fibrosis of Repair]
8) “Abnormal movement patterns can have important influences on the connective tissues that surround and infiltrate muscles.” [Very important because the subluxation complex includes abnormal movement patterns.]
9) “A hallmark of connective tissue is its plasticity or ‘remodeling’ in response to varying levels of mechanical stress.” [This is important because it implies that spinal adjusting can initiate remodeling of abnormal connective tissues.]
10) “Both increased stress due to overuse, repetitive movement and/or hypermobility, and decreased stress due to immobilization or hypomobility can cause changes in connective tissue.” [Both increased and decreased motion are deleterious.]
11) A chronic local increase in stress leads to micro-injury and inflammation. [Subluxation can cause micro-injury and inflammation.]
12) “A consistent absence of stress leads to connective tissue atrophy, architectural disorganization, fibrosis, adhesions and contractures.” [Fibrosis]
13) “Fibrosis can be the direct result of hypomobility or the indirect result of hypermobility via injury and inflammation.” [Very Important]
14) During the early phase of immobilization, loss of muscle length is primarily due to shortening of muscle-associated connective tissue, which is later followed by actual shortening of muscle fibers.
15) Muscle connective tissue fibrosis promotes hypomobility. “Connective tissue fibrosis is detrimental, as it leads to increased tissue stiffness and further movement impairment.” [Important: fibrosis]
16) “Tissue microinjury, inflammation and fibrosis not only can change the biomechanics of soft tissue (e.g., increased stiffness) but also can profoundly alter the sensory input arising from the affected tissues.” [Very Important: Many contend that the tissue changes associated with the subluxation alter the afferent input into the central nervous system, which is the nerve interference of the subluxation.]
17) “Connective tissue is richly innervated with mechanosensory and nociceptive neurons.” [Very Important]
18) Activation of nociceptors can contribute to the development or worsening of fibrosis and inflammation, causing even more tissue stiffness and movement impairment. [Important]
19) Chronic low back pain may be caused by pathological connective tissue fibrosis, which causes adverse changes in movement. This is well documented in ligaments and joint capsules. [Very Important] This pathological connective tissue fibrosis is plastic and can, therefore, be remodeled. However, the remodeling must take place over time.
20) “In fibrosed connective tissue and muscle, blood and lymphatic flow may be chronically compromised by the disorganized tissue architecture and, thus, vulnerable to unusual muscle activity (e.g., beginning a new work activity or sport), or to conditions causing further decrease in perfusion such as prolonged sitting.”
21) Pain leads to reduced motion, and movement restriction increases fibrosis, “setting the patient up for more painful episodes.” [Very Important: fibrosis]
22) “In addition to its role in the pathological consequences of immobility and injury, the dynamic and potentially reversible nature of connective tissue plasticity may be key to the beneficial effects of widely used physical therapy techniques as well as ‘alternative’ treatments involving external application of mechanical forces (e.g., massage, chiropractic manipulation, acupuncture), changes in specific movement patterns (e.g., movement therapies, tai chi, yoga) or more general changes in activity levels (e.g., increased recreational exercise).”
23) “Manual or movement-based treatments have the advantage of not causing drug-induced side effects (e.g., gastritis, sedation),” but excessive motion may lead to inflammation.
24) A “carefully applied direct tissue stretch may be necessary in cases of long standing hypomobility with pronounced fibrosis and stiffness.” [Very Important, as an adjustment may be considered to be a “carefully applied direct tissue stretch.”]
Dr. Dan Murphy graduated magna cum laude from Western States Chiropractic College in 1978. He received Diplomat status in Chiropractic Orthopedics in 1986. Since 1982, Dr. Murphy has served part-time as undergraduate faculty at Life Chiropractic College West, currently teaching classes to seniors in the management of spinal disorders. He has taught more than 2000 postgraduate continuing education seminars. Dr. Murphy is a contributing author to both editions of the book Motor Vehicle Collision Injuries and to the book Pediatric Chiropractic.