Key Points from Dan Murphy
1) An explanation for the soft tissue pain experienced by patients with fibromyalgia was that muscle energy production of ATP may be compromised.
[This has significant relevance to low level laser therapy because of their ability to increase the production of cellular ATP].
2) Also, abnormal blood flow may deprive muscle of sufficient oxygen and other nutrients.
[This has significant relevance to chiropractic because of the evidence that chiropractic spinal adjustments improve spinal mechanics, which inhibits the sympathetic nervous system and improves blood flow.]
3) The muscles of patients with fibromyalgia are deficient in ATP and magnesium.
4) Malic acid and magnesium play a pivotal role in mitochondrial ATP synthesis.
5) Malic acid is “widely distributed in the vegetable kingdom including concentrations of 4 to 8 g/l of apple juice.”
6) Malic acid plus magnesium can increase mitochondrial production of ATP energy.
7) The best results were observed from “use of a higher dosage and longer duration of treatment” with malic acid and magnesium.
8) Study results “indicate that it may be beneficial on the painful fibromyalgia symptoms in dosages in excess of 8 tablets/day for up to 6 months.”
[8 tablets X 200 mg per tablet = 1600 mg malic acid per day]
[8 tablets X 50 mg per tablet = 400 mg magnesium per day]
9) The proposed mechanism for the benefit of malic acid plus magnesium supplementation is that they “increase production of ATP.”
This article suggests that the minimum dosage should be 6 tablets per day (2 with each meal), which would supply 1764 mg of malic acid and 354 mg of magnesium.
Another article suggests that the optimal dosage should be 9 tablets per day (3 with each meal), supplying 2646 mg of malic acid and 531 mg of magnesium.
This article suggests that the minimum dosage should be 6 tablets per day (2 with each meal), which would supply 1764 mg of malic acid and 354 mg of magnesium.
Another article suggests that the optimal dosage should be 9 tablets per day (3 with each meal), supplying 2646 mg of malic acid and 531 mg of magnesium.
Dr. Dan Murphy graduated magna cum laude from Western States Chiropractic College in 1978. He received Diplomat status in Chiropractic Orthopedics in 1986. Since 1982, Dr. Murphy has served part-time as undergraduate faculty at Life Chiropractic College West, currently teaching classes to seniors in the management of spinal disorders. He has taught more than 2000 postgraduate continuing education seminars. Dr. Murphy is a contributing author to both editions of the book Motor Vehicle Collision Injuries and to the book Pediatric Chiropractic.